Concurrent CFD simulations were conducted to predict both flow field-based and particle-based dispersion parameters that captured different measures of turbulence. Aerosolization experiments were performed using cascade impaction to determine mean device emitted dose (ED) and mass median aerodynamic diameter (MMAD). Five DAC-unit geometries with varying orifice outlet sizes, configurations, and protrusion distances were considered. The dose aerosolization and containment (DAC) unit DPI utilizes inlet and outlet air orifices designed to maximize the dispersion of spray dried powders, typically with low air volumes (~ 10 ml) and relatively low airflow rates (~ 3 L/min). The objective of this study was to develop quantitative correlations for predicting the aerosolization behavior of a newly proposed dry powder inhaler (DPI). Computational fluid dynamics (CFD) modeling offers a powerful tool for the development of drug delivery devices using a first principles approach, but has been underutilized in the development of pharmaceutical inhalers.
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